trenbolone enanthate side effects

Diseases of the trenbolone enanthate side effects cardiovascular system (including atrioventricular and intraventricular block),  disorders (epilepsy, Parkinson’s disease), diabetes, hyperthyroidism, hyperparathyroidism, infection, psoriasis, renal failure, urinary retention, disturbance of water and electrolyte exchange (dehydration – simultaneous treatment with diuretics, salt-free diet, the delay of ions of Na + , vomiting, diarrhea).

Dosing and Administration

Inside (for 3-4 hours, the last time – before going to bed), the food, the initial dose – 0.6-0.9 g / day, followed by an increase to 1.2 g / day, then increase the dose daily for 0.3 g to achieve a daily dose of 1.5-2.1 g; the maximum daily dose – 2.4 g In the period of selection of therapy ion concentration of Li + in the plasma must not be lower than 0.6 and not higher than 1.2-1.6 mmol / l. At doses greater than 2 g / day, duration of treatment -. 1-2 weeks
after the disappearance of manic symptoms daily dose is gradually reduced to a prophylactic dose (0.6-1.2 g). If after a dose reduction once again showing signs of mania, the dosage is increased.
In acute manic state therapeutic concentration of ions of Li + in the blood should be 0.8-1.2 mmol / l, with supportive care – 0.4-0.8 mmol / l ; if the concentration of the ions Li + exceeds 1.2 mmol / l, should reduce the daily dose.
A positive result is manifested prophylactic monotherapy while maintaining stable blood concentration in an adult within 0.4-0.8 mmol / L of at least 6 months, children – dose, which allows you to maintain therapeutic concentrations in the range 0.5-1 mg / dL.

Side effects:
Dyspepsia, discomfort, myasthenia gravis, tremor, weakness, lethargy, increased thirst, arrhythmia, inhibition of hematopoiesis, hypothyroidism, leukocytosis, increased body weight.
With prolonged use trenbolone enanthate side effects – a violation of concentration ability of the kidneys, dysarthria, hyperreflexia, a decrease in urine output, collapse, coma .

Overdose

Symptoms: Early – diarrhea, drowsiness, loss of appetite, muscle weakness, nausea, vomiting, dysarthria, tremor; later – dizziness, blurred vision, impaired coordination of movement, polyuria, confusion, severe cramps. Treatment: As a first aid expedient introduction into a large amount of fluid and salt (sodium ions Na + ); in severe cases require hospitalization.

Interaction with other drugs Lithium drugs reduce the pressor effect of norepinephrine, as well as the action of mineral-corticosteroid fludrocortisone, increase neurotoxic effects of haloperidol;phenothiazines reduce absorption in the gastrointestinal tract, which leads to a reduction in blood concentration of 40%; reduce the antidiuretic effect of carbamazepine, desmopressin, lipressina, hormones posterior pituitary (antidiuretic hormone); increase the risk of hypothyroidism in combination with calcium iodide, iodinated glycerol, potassium iodide; enhance the muscle relaxant effect of atracurium, pancuronium, ditilina; reducing central stimulating effects of amphetamines. Formulations containing sodium ions  or foods reduce efficacy . Urea, aminophylline caffeine, dyphylline, choline theophyllinate, theophylline increases the excretion of ions kidneys and impair its pharmacological action. Metronidazole, fluoxetine, diuretics, non-narcotic anti-inflammatory drugs , angiotensin converting enzyme inhibitors – slow renal excretion of ions  and increase its toxic effects. molindone stimulates the development of neurotoxicity (confusion, delirium, seizures, sleepwalking or abnormal EEG changes); methyldopa increases the risk of drug toxicity  even in normal concentrations in plasma; blockers “slow” calcium channels (BCCI) increase the incidence of complications neurotoxicity (ataxia, tremors, nausea, vomiting, diarrhea, ringing in the ears). When combined trenbolone enanthate side effects with antipsychotic agents, timoleptikov, neuroleptics may increase body weight. Incompatible with ethanol containing soup mi drinks.

special instructions

During the first month of therapy ion concentration of Li + in the plasma is determined on a weekly basis in the future reaches a stable concentration control is carried out on a monthly basis, then – in 2-3 months. Blood samples were always taken in the morning, i.e. over 12 hours after the last dose at night or 24 hours after receiving a single dose in the morning.
In the beginning of trenbolone enanthate side effects the treatment can cause a depression or mania.

Effects on ability to drive vehicles and mechanisms
In the period of treatment must be careful when driving and occupation of other potentially hazardous activities that require high concentration and psychomotor speed reactions.

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