Epilepsy Adults and children (over 12 years), epilepsy (partial and generalized seizures, including tonic-clonic seizures and seizures with Lennox-Gastaut syndrome) in a combination therapy or monotherapy. Children from 3 to 12 years of epilepsy (partial and generalized seizures, including tonic-clonic seizures and seizures with Lennox-Gastaut syndrome) in a combination therapy. After reaching epilepsy control against the background of a combination therapy, concomitant antiepileptic drugs trenbolone enanthate gains may be canceled and the reception continued lamotrigine monotherapy. Monotherapy of typical absence seizures.
- Bipolar disorder Adults (18 years and older) for the prevention of mood disorders (depression, mania, hypomania, mixed episodes) in patients with bipolar disorder.Contraindications
: Hypersensitivity to lamotrigine or to any component of the drug. Children under 3 years of age (for a given dosage form).
Chronic renal failure, allergic reaction, or a skin rash trenbolone enanthate gains on the use of other anti-epileptic drugs in history.
The study of the reproductive function of animals did not reveal violations of fertility in the appointment of lamotrigine. Studies on the effect of lamotrigine on human fertility have not been conducted. Pregnancy Post-marketing observations have documented the pregnancy outcomes of nearly 1,000 women treated with lamotrigine monotherapy during the first trimester of pregnancy. The resulting data showed that the risks of major congenital anomalies are comparable to the average risk in the general population. However, according to other sources, we can not exclude an increased risk of “cleft lip”. Lamotrigine should be administered during pregnancy only if the expected therapeutic benefit to the mother outweighs risk to the fetus. Physiological changes that develop during pregnancy may affect lamotrigine levels and / or therapeutic effect. There are reports of decrease in the concentration of lamotrigine during pregnancy. Appointment of lamotrigine pregnant should be provided appropriate management of patients. Lactation Information on the use of lamotrigine during breast-feeding is limited. According to preliminary data lamotrigine passes into breast milk in concentrations corresponding to about 40-60% of the concentration in maternal plasma. A small number of babies who were breastfed, lamotrigine plasma levels reach the point where can develop pharmacological effect. It is necessary to correlate the potential benefits of breast milk feeding and the potential risk of side effects in the infant.
Dosage and administration
The tablets are taken in.
In the event trenbolone enanthate gains of renewed reception Seyzara physicians should evaluate the need to improve the maintenance dose in patients who stop taking the drug for any reason, since high initial doses and exceeding the recommended doses are associated with a risk of severe skin rash. The more time has passed after the last dose, the dose should be increased to support more cautious. If the time after discontinuation of more than 5 half-lives, the Seyzara dose should be increased to maintenance under the relevant scheme. Therapy should not be reopened Seyzarom patients, discontinuation of treatment which was associated with the appearance of rash, unless the potential benefits of this therapy outweigh the possible risks is obvious.
Epilepsy Monotherapy epilepsy patients Adults and children over 12 years – Table.1 Initial dose Seyzara monotherapy is 25 mg once a day for 2 weeks, followed by increasing doses up to 50 mg once a day for 2 weeks. Dose should then be increased to 50-100 mg every 1-2 weeks until the optimal therapeutic effect is achieved. Standard maintenance dose to achieve the optimal therapeutic effect is 100-200 mg per day in one or two steps. Some patients in order to achieve the desired therapeutic effect is required dose to 500 mg / day. Children aged 3 to 12 years – Table. 2 children from 3 to 12 years old at the beginning of therapy and to increase the dose, tablets with a dosage of 5 mg.The starting dose Seyzara monotherapy patients with typical absence seizures of 0.3 mg / kg body weight / day in one or two stages during 2 weeks, followed by increasing doses up to 0.6 mg / kg body weight / day in one or two stages over two weeks. dose should then be possible to raise the 0.6 mg / kg every 1-2 weeks until until you reach the optimal therapeutic effect. Usual maintenance dose for achieving the optimal therapeutic effect is from 1 to 15 mg / kg body weight / day in one or two steps, although some patients with typical absences to achieve a therapeutic effect, higher doses are required.Because of the risk of rash should not exceed the initial dose and increase the dose recommended by mode. In the combination therapy of patients with epilepsy : Adults and children over 12 years – Table. 1in patients who are already receiving valproic acid in combination with other or without initial dose Seyzara is 25 mg every other day for 2 weeks later – 25 mg once a day for 2 weeks.
Then, the dose should be increased by up to 25-50 mg / day every 1-2 weeks until the optimal therapeutic effect is achieved. Usual maintenance dose for achieving the optimal therapeutic effect is 100-200 mg per day in one or two steps. Those patients receiving concomitant therapy with or other drugs that stimulate lamotrigine glucuronidation, with or without other (except valproevoy acid ), the initial trenbolone enanthate gains dose is Seyzara 50 mg once a day for 2 weeks later -. 100 mg / day in two divided doses for 2 weeks then the dose is increased by up to 100 mg every 1-2 weeks until It is reached the optimal therapeutic effect.The usual maintenance dose is 200-400 mg daily in two divided doses. Some patients to achieve the desired therapeutic effect may require a dose of 700 mg / day. Patients who take oxcarbazepine in combination with any other inducers or inhibitors of glucuronidation of lamotrigine or without initial dose Seyzara is 25 mg once a day for 2 -x weeks later – 50 mg / day for a time of 2 weeks. Then, the dose is increased to a maximum of 50-100 mg every 1-2 weeks until the optimal therapeutic effect is achieved. The usual maintenance dose is 100-200 mg per day in one or two steps.