Symptoms: drowsiness, depression of consciousness of varying severity, paradoxical excitement, reduced reflexes to areflexia, decreased response to pain stimuli, dysarthria, ataxia, blurred vision (nystagmus), tremor, bradycardia, decreased blood pressure, collapse, depression of cardiac and respiratory (up up to apnea) activity, coma.
Treatment: gastric lavage, forced diuresis, symptomatic therapy (maintenance of respiration and blood pressure), mechanical ventilation. As a specific antagonist flumazenil is used (in the hospital).
Hemodialysis – is ineffective. Benzodiazepine trenbolone enanthate dosage antagonist flyumazenil not indicated for patients with epilepsy who were treated with benzodiazepines. In such patients antagonistic action with respect to benzodiazepines can provoke the development of epileptic seizures.
The interaction with other drugs
In the application of diazepam together with other drugs can occur following coupling reaction:
– with inhibitors of monoamine oxidasetrenbolone enanthate dosage, strychnine – antagonism diazepine effects;
– with hypnotics, sedatives, narcotic analgesics, other tranquilizers, benzodiazepines, muscle relaxants, agents for general anesthesia, antidepressants, neuroleptics, alcohol – sharp increase inhibitory action on the central nervous system
– with cimetidine, disulfiram, erythromycin, fluoxetine, as well as oral contraceptives and estrogensoderjath drugs which competitively inhibit hepatic metabolism (oxidation process) – may slow the metabolism of diazepam and its increased plasma concentrations;
– isoniazid, ketoconazole, and metoprolol also slow diazepam metabolism and increase its concentration in blood plasma;
– propranolol and valproic acid increases the level of diazepam in blood plasma;
– rifampicin may enhance metabolism of diazepam and thus reduce its concentration in the blood plasma;
– inducers of microsomal liver enzymes – reduce efficiency.
antihypertensives may increase the severity of blood pressure lowering.
Antacid drugs reduce the rate of absorption of diazepam from the gastrointestinal tract.
Clozapine – may increase the respiratory depression.
in an application with cardiac glycosides – possible increase in their concentration in the blood serum and the development of digitalis intoxication (due to the concurrent connection with plasma proteins).
Reduces levodopa efficacy in patients with Parkinson’s.
omeprazole prolongs the elimination of diazepam.
stimulants reduce the activity of the drug.
The potentially may increase zidovudine toxicity.
Theophylline (used in low doses) may reduce the sedative effect.
Premedication with diazepam trenbolone enanthate dosage reduces the dose of fentanyl required for the introduction of general anesthesia, and reduces the occurrence of general anesthesia.
requires particular caution in the appointment of diazepam in severe depression since the drug can be used for the implementation of suicidal intentions.